The Potential Application of Natural Ingredient Ivy Extract Hederagenin in Health Products

Apr 29,2025
Category:Nutraceutical Ingredients

As a leading company in the field of plant extracts, Green Spring Technology has always been committed to discovering natural active ingredients with application potential. Recently, based on significant scientific research advancements, we are proud to introduce our high-purity Hederagenin raw material—a natural pentacyclic triterpenoid compound derived from Chinese ivy and other plants. This component, with its unique structure and biological activity, is increasingly becoming a hot raw material for product innovation in the health supplements, functional foods, and beverages industries.

 

Hederagenin is widely found in plants such as Chinese ivy, Cynanchum, and Patrinia, typically existing in the form of saponins, and possesses excellent development and application potential. Green Spring Technology employs advanced extraction and purification processes to ensure the raw material’s consistent purity and superior quality, meeting multiple international standards.

  

We offer comprehensive technical documentation, compliance support, and customised application solutions to help businesses develop next-generation differentiated health products.


As research into hederagenin derivatives (such as α-hederagenin) continues to deepen, multiple experiments have shown that this compound exhibits potential activity in cellular metabolism and oxidative stress-related mechanisms, opening new directions for functional ingredient applications.

 

Based on existing scientific research, Green Spring Technology has officially launched a standardised ivy extract powder with a stable content of 5% hederagenin, the main active ingredient. This raw material demonstrates potential application value in multiple functional areas, including respiratory health, joint comfort, liver and nervous system support, and metabolic regulation, making it suitable for the development and formulation upgrades of dietary supplements, functional foods, and beverages.

 

Ivy Leaf Extract 5% Hederagenin

Green Spring Technology remains committed to science-based research, strictly adhering to international standards such as EP, USP, and JP to ensure consistent purity, accurate active ingredient content, and rigorous quality control for every batch of raw materials, fully meeting export market regulatory requirements. We also offer customised raw material solutions tailored to specific customer needs, including different specifications and stability-optimised formulations, to provide reliable support for your product innovation.

 

We invite health supplement and functional food companies, as well as R&D experts, to contact Green Spring Technology to obtain samples, technical documentation, and compliance files for Ivy Extract (5% Hederagenin), and collaborate with us to create the next generation of scientifically trusted health products! Please contact us at helen@greenspringbio.com or WhatsApp: +86 13649243917

 

Reference

[1]Zeng J,Huang T,Xue  M.et al.Current knowledge and development of hederagenin  as  a  promising  medicinal agent:a  comprehensive review [J] .  RSC Adv , 2018 , 8(43) : 24188-24202 .  DOI :  10 . 1039/ c8ra03666g.

[2]Zhang D ,  Sun  J ,  Yang  B ,   et  al.   Therapeutic  effect  of tetrapanax papyriferus and hederagenin on chronic neuropathic pain of chronic constriction injury  of  sciatic  nerve rats based on  KEGG  pathway prediction and experimental verification[J] .   Evid Based  Complement Alternat Med , 2020 ,2020 :2545806.  DOI :  10. 1155/2020/2545806.

[3]Li Y ,  Dong J ,  Shang Y ,  et al.   Anti-inflammatory effects of heder- agenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model[J] .  RSC Adv , 2019 , 9(45) : 26238-26247 .  DOI :  10 . 1039/c9ra02043h .

[4]Ma W ,  Huang  Q ,  Xiong  G ,  et  al.   The  protective  effect  of heder- agenin on  pulmonary  fibrosis  by  regulating  the Ras/JNK/NFAT4 axis in rats[J] .  Biosci  Biotechnol  Biochem ,  2020 , 84 (6) : 1131 -1138 .  DOI :  10 . 1080/09168451 . 2020 . 1721263 .

[5]Wang  L ,   Zhao  M .    Suppression  of  NOD-like  receptor  protein 3 inflammasome activation and macrophage M1  polarization by heder- agenin contributes to attenuation of sepsis-induced acute lung injury in rats[J] .   Bioengineered ,  2022 , 13 (3 )  : 7262-7276 .   DOI :   10 .  1080/21655979 . 2022 . 2047406 .

[6]Lee  CW ,  Park  SM ,  Zhao R ,  et  al.   Hederagenin ,  a  major component of  clematis   mandshurica   ruprecht   root ,   attenuates   inflammatory responses in RAW 264 . 7  cells  and  in mice [ J] .    Int  Immunop- harmacol ,  2015 ,  29  ( 2 ) : 528-537 .    DOI :   10 .   1016/j .   intimp .  2015 . 10 . 002 .

[7]Kim  GJ ,  Song  DH ,  Yoo  HS ,  et  al.   Hederagenin  supplementation alleviates the pro-inflammatory and apoptotic response to alcohol in rats[J] .  Nutrients , 2017 , 9(1) : 41 .  DOI :  10 . 3390/nu9010041 .

Follow Us
Back to the List
Prev

Apple Extract 80% Polyphenols Enhances Natural Antioxidant Product Formulations

Next

Exploring the Potential of Ivy Leaf Extract Hederagenin in Functional Food Formulations

Recommend Information

Need More Information, Please Get in Touch.